ea0063gp202 | Diabetes: Pharmacotherapy | ECE2019
da Rocha Aline Franco
, Junior Paulo Sergio Pereira
, Calefi Gabriela Simonetti
, Morimoto Helena Kaminami
, Marquezine Guilherme Figueiredo
, Mazzuco Tania Longo
, de Faria Eliana Cotta
, Urbano Mariana Ragassi
, Carrilho Alexandre Jose Faria
Context: Sodium-glucose cotransporter 2 (SGLT2) inhibitors induce glycosuria and improve glycemic control, β cell function and insulin sensitivity in type 2 diabetes mellitus (DM2). On the other hand, these drugs predispose to diabetic ketoacidosis by increasing the tonus of glucagon. Glucagon acts on the liver and has no relevant effect on peripheral lipolysis and release of free fatty acids (FFA) as a substrate for ketogenesis, an action attributed to growth hormone (GH...